cGMP (guanosine 3',5'-cyclic monophosphate) transport across human erythrocyte membranes.

@article{Wu2005cGMP3,
  title={cGMP (guanosine 3',5'-cyclic monophosphate) transport across human erythrocyte membranes.},
  author={C Wu and Hannah Woodcock and Stephen Hladky and Margery A. Barrand},
  journal={Biochemical pharmacology},
  year={2005},
  volume={69 8},
  pages={1257-62}
}
Human erythrocytes produce cGMP that can be eliminated by phosphodiesterases or active efflux transporters. The efflux can be studied under controlled conditions as ATP-dependent uptake into inside-out membrane vesicles. However, widely differing values for the transport rates have been reported. We have here examined factors that influence the uptake rates measured and thus may explain these discrepancies. Both the ionic composition of the buffer used during uptake and the mode of vesicle… CONTINUE READING