cGAS is essential for the antitumor effect of immune checkpoint blockade.

@article{Wang2017cGASIE,
  title={cGAS is essential for the antitumor effect of immune checkpoint blockade.},
  author={Hua Wang and Shuiqing Hu and Xiang Chen and Heping Shi and Chuo Chen and Lijun Sun and Zhijian J Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 7},
  pages={1637-1642}
}
cGMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses. cGAS catalyzes the synthesis of cGAMP, which functions as a second messenger that binds and activates the adaptor protein STING to induce type I interferons (IFNs) and other immune modulatory molecules. Here we show that cGAS is indispensable for the antitumor effect of immune checkpoint blockade in mice. Wild-type, but not cGAS-deficient, mice exhibited slower growth of B16 melanomas in response… CONTINUE READING
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