cFos ensembles in the dentate gyrus rapidly segregate over time and do not form a stable map of space

@article{LamotheMolina2022cFosEI,
  title={cFos ensembles in the dentate gyrus rapidly segregate over time and do not form a stable map of space},
  author={Paul J. Lamothe-Molina and Andreas Franzelin and Lennart Beck and Dong Li and Lea Auksutat and Tim Fieblinger and Laura Laprell and Joachim Alhbeck and Christine E. Gee and Matthias Kneussel and Andreas Karl Engel and Claus C. Hilgetag and Fabio Morellini and Thomas G. Oertner},
  journal={bioRxiv},
  year={2022}
}
Transgenic cFos reporter mice are used to identify and manipulate neurons that store contextual information during fear learning. It is not clear, however, how spatial information acquired over several training days is integrated in the hippocampus. Using a water maze task, we observed that cFos expression patterns in the dentate gyrus are temporally unstable and shift daily. Surprisingly, cFos patterns did not get more stable with increasing spatial memory precision. Despite the fact that cFos… 
2 Citations

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