cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

@article{Lusson1993cDNASO,
  title={cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.},
  author={Jean Ren{\'e} Lusson and Didier Vieau and Jos{\'e}e Hamelin and Robert Day and Michel Chr{\'e}tien and Nabil G Seidah},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 14},
  pages={6691-5}
}
By using reverse transcriptase/PCR and oligonucleotide sequences derived from conserved segments (including the conserved RRGDL sequence) of the known proprotein convertases (PCs) PC1, PC2, furin, and PC4, we identified a subtilisin/kexin-like PC called PC5 in both mouse and rat tissues. The composite structure (2.85 kb) was deduced from the analysis of the reverse transcription/PCR products combined with the sequence from a clone isolated from a cDNA library made from corticotropin-activated… CONTINUE READING

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