cDNA sequences and organization of IgM heavy chain genes in two holostean fish.

@article{Wilson1995cDNASA,
  title={cDNA sequences and organization of IgM heavy chain genes in two holostean fish.},
  author={Melanie R. Wilson and E van Ravenstein and Norman W. Miller and L. William Clem and Darlene L. Middleton and Gregory W. Warr},
  journal={Developmental and comparative immunology},
  year={1995},
  volume={19 2},
  pages={153-64}
}
Immunoglobulin M heavy chain (mu) sequences of two holostean fish, the bowfin, Amia calva, and the longnose gar, Lepisosteus osseus, were amplified from spleen mRNA by RACE-PCR, cloned, and sequenced. Each mu chain showed the conserved four constant domain structure typical of a secreted mu chain. Southern blot analyses with specific heavy chain variable (VH) and constant (CH) region probes suggest that both fish possess an IgH locus that resembles that of the teleosts, amphibians, and mammals… CONTINUE READING

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