cDNA profiling of epileptogenesis in the rat brain.

  title={cDNA profiling of epileptogenesis in the rat brain.},
  author={Katarzyna Lukasiuk and Laura Kontula and Asla Pitk{\"a}nen},
  journal={The European journal of neuroscience},
  volume={17 2},
Symptomatic temporal lobe epilepsy typically develops in three phases: brain insult --> latency period (epileptogenesis) --> recurrent seizures (epilepsy). We hypothesized that remodeling of neuronal circuits underlying epilepsy is associated with altered gene expression during epileptogenesis. Epileptogenesis was induced by electrically triggered status epilepticus (SE) in rats. Animals were continuously monitored with video-EEG, and the hippocampus and temporal lobe were collected either… CONTINUE READING


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