cDNA microarray-based identification of genes and pathways associated with oxaliplatin resistance

@article{Samimi2004cDNAMI,
  title={cDNA microarray-based identification of genes and pathways associated with oxaliplatin resistance},
  author={Goli Samimi and Gerald H Manorek and Rob Castel and James K. Breaux and Tim Cheng and Charles C. Berry and Gerrit Los and Stephen B. Howell},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={55},
  pages={1-11}
}
In order to identify genes whose expression is associated with resistance to the chemotherapeutic agent oxaliplatin, transcripts differentially expressed between an oxaliplatin sensitive and a stably resistant subline were compared in six independent replicates using Stanford cDNA microarrays for five cell lines. “Significance analysis of microarrays” (SAM) was used to identify genes whose expression was statistically significantly different in the sensitive versus resistant members of each… CONTINUE READING