cDNA microarray analysis of gene expression in coeliac disease jejunal biopsy samples.

@article{JuutiUusitalo2004cDNAMA,
  title={cDNA microarray analysis of gene expression in coeliac disease jejunal biopsy samples.},
  author={Kati Juuti-Uusitalo and Markku J M{\"a}ki and Katri Kaukinen and Pierre Collin and Tapio Visakorpi and Mauno Vihinen and Heikki Kainulainen},
  journal={Journal of autoimmunity},
  year={2004},
  volume={22 3},
  pages={249-65}
}
In coeliac disease in the jejunum of a genetically susceptible person wheat gliadin and related prolamins from rye and barley trigger an immunological reaction, which induces small-bowel mucosal transformations, villous atrophy and crypt hyperplasia. Though CD4+ specific T cells, intraepithelial lymphocytes, infiltrating plasma cells and autoantibodies are known to have an effect on the coeliac disease, the pathogenic mechanisms leading to the tissue injury remain to be elucidated. Our aim was… CONTINUE READING
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