cDNA microarray analysis identifies genes induced in common by peptide growth factors and androgen in human prostate epithelial cells.

@article{York2005cDNAMA,
  title={cDNA microarray analysis identifies genes induced in common by peptide growth factors and androgen in human prostate epithelial cells.},
  author={Timothy P. York and S Stephen R. Plymate and Peter S. Nelson and Lindon J. Eaves and Heather D. Webb and J. Latane Ware},
  journal={Molecular carcinogenesis},
  year={2005},
  volume={44 4},
  pages={
          242-51
        }
}
Prostate cancer cells initially require androgen for continued proliferation, but invariably become androgen independent or unresponsive and recur after treatment by androgen ablation. Exploitation of common signaling components downstream of their specific receptors (i.e., androgen receptor (AR), insulin-like growth factor 1 (IGF-1) receptor, and epidermal growth factor (EGF) receptor) could provide a mechanism by which androgen independent cells survive and proliferate. Our objective was to… CONTINUE READING
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