cDNA macroarray analysis of gene expression changes in rat brain after a single administration of a 2-aminoadamantane derivative

  title={cDNA macroarray analysis of gene expression changes in rat brain after a single administration of a 2-aminoadamantane derivative},
  author={Yu. V. Vakhitova and Renat S. Yamidanov and Vener Absatarovich Vakhitov and Sergey B. Seredenin},
  journal={Molecular Biology},
The Atlas™ Rat cDNA Expression Array (BD Biosciences, United States) has been used to analyze changes in the expression of 588 genes in rat brain cells in response to a single administration of Ladasten, a 2-aminoadamantane derivative that has psychostimulating and anxiolytic effects. The analysis of hybridization on macroarrays, confirmed by the results of real-time quantitative RT-PCR, has demonstrated that Ladasten alters the expression of 12 genes in the rat brain. The GAT3 and CARBH genes… 
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