cDNA encodes Xenopus P2Y(1) nucleotide receptor: expression at the neuromuscular junctions.

@article{Cheng2003cDNAEX,
  title={cDNA encodes Xenopus P2Y(1) nucleotide receptor: expression at the neuromuscular junctions.},
  author={Anthony W. M. Cheng and Ling W. Kong and Edmund Kwok-kwan Tung and Nina L. Siow and Roy C. Y. Choi and S. Q. Zhu and Benjamin H Peng and Karl Wah-keung Tsim},
  journal={Neuroreport},
  year={2003},
  volume={14 3},
  pages={351-7}
}
A cDNA encoding P2Y(1) receptor was isolated by cross-hybridization with chicken homolog. The deduced amino acid sequence of P2Y(1) receptor with 361 amino residues is 80-85% identical to human, rodent and avian homologs. When the cDNA was expressed in mammalian cells, the activation of P2Y(1) receptor by adenine nucleotides stimulated the accumulation of inositol phosphate, and adenosine 3',5'-bismonophosphate (A3P5P) or other antagonists blocked its action; these pharmacological properties… CONTINUE READING

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