cDNA cloning of the beta subunit of teleost thyrotropin.

  title={cDNA cloning of the beta subunit of teleost thyrotropin.},
  author={Meguru Ito and Yasushi Koide and Naofumi Takamatsu and Hiroshi Kawauchi and Tadayoshi Shiba},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 13},
cDNA clones encoding the beta subunit of thyrotropin (thyroid-stimulating hormone; TSH) were isolated from a cDNA library made from the pituitaries of immature rainbow trout and sequenced. The precursor of rainbow trout TSH beta consists of 147 aa, which can be cleaved into a signal peptide (20 aa) and a mature protein (127 aa) containing one potential N-glycosylation site and 12 cysteine residues. The protein showed highest homology with human TSH beta (51%) and lesser homology with human… CONTINUE READING