cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.

@article{Lehmeier1994cDNACO,
  title={cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.},
  author={Thomas Lehmeier and Veronica A. Raker and Hannes Hermann and Reinhard L{\"u}hrmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 25},
  pages={
          12317-21
        }
}
The major small nuclear ribonucleoproteins (snRNPs) U1, U2, U4/U6, and U5 share a set of common proteins denoted B/B', D1, D2, D3, E, F, and G which play an important part in the biogenesis of the snRNPs. In addition, there is a link between the common proteins and autoimmunity; the three D proteins, together with B/B', are the major autoantigens for the so-called anti-Sm antibodies often produced by patients suffering from systemic lupus erythematosus. Here we describe the characterization of… CONTINUE READING
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