cDNA cloning of a novel CYP3A from rat brain.

  title={cDNA cloning of a novel CYP3A from rat brain.},
  author={Hong Wang and Hoshiko Kawashima and Henry W. Strobel},
  journal={Biochemical and biophysical research communications},
  volume={221 1},
One full length cDNA clone, designated 3aH15, was isolated from a control male rat brain cDNA library. 3aH15 encoded a protein composed of 503 amino acid residues. The deduced amino acid sequence of 3aH15 was 92% identical to Cyp3a-13 and had a 68.4% to 76.5% homology with the other reported CYP3A sequences. Clone 3aH15 was thus named CYP3A9. No significant induction of the CYP3A9 expression in rat brain by dexamethasone was observed by Northern blot analysis. CYP3A9 cDNA was expressed in E… CONTINUE READING

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