cDNA cloning and chromosomal localization of the human ciliary neurotrophic factor gene

  title={cDNA cloning and chromosomal localization of the human ciliary neurotrophic factor gene},
  author={Hidehiro Yokoji and Takeshi Ariyama and Ryosuke Takahashi and Johji Inazawa and Hidemi Misawa and Takeo Deguchi},
  journal={Neuroscience Letters},


Human ciliary neurotrophic factor: localization to the proximal region of the long arm of chromosome 11 and association with CA/GT dinucleotide repeat.
Using a rodent-human mapping panel and fluorescence in situ hybridization, a single copy of the gene for human CNTF is localized to the proximal long arm of chromosome 11 and a polymorphic tandem CA/GT dinucleotide repeat associated with the humanCNTF gene is identified.
Cloning and expression of human ciliary neurotrophic factor.
The cloning of the entire genomic sequence encoding human CNTF and its primary structure is reported, providing a basis for understanding the role of CNTF in nervous system physiology and pathology.
Recombinant Human and Rat Ciliary Neurotrophic Factors
The human ciliary neurotrophic factor (CNTF) gene was identified and cloned, based on homology with the recently cloned rat cDNA, and appears to contain a single intron separating two protein coding exons.
Chromosomal localization of the human ciliary neurotrophic factor gene (CNTF) to 11q12 by fluorescence in situ hybridization.
The human gene for ciliary neurotrophic factor (CNTF) was previously assigned to chromosome 11 by analysis of a panel of somatic cell hybrids by using fluorescent in situ hybridization to regionally localize the human CNTF gene on chromosome 11.
Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
The complementary DNA-deduced amino-acid sequence and subsequent expression of cDNA clones covering the entire coding region in HeLa-cells indicate that CNTF is a cytosolic protein, and shows thatCNTF is not a target-derived neurotrophic factor.
Rat ciliary neurotrophic factor (CNTF): Gene structure and regulation of mRNA levels in glial cell cultures
In astrocyte‐enriched cultures, upregulation of CNTF mRNA levels was observed after treatment with IFN‐γ and down‐regulated in these cells by treatments that elevate intracellular cyclic AMP and by members of the fibroblast growth factor (FGF) family.
A null mutation in the human CNTF gene is not causally related to neurological diseases
A null mutation in the human ciliary neurotrophic factor gene (CNTF) is reported, showing a G to A transition producing a new splice acceptor site and the resulting mRNA species codes for an aberrant protein.