cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase.

@article{Shao1994cDNACA,
  title={cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase.},
  author={Haipeng Shao and Liang Lou and Akhilesh Pandey and Elena B Pasquale and Vishva M. Dixit},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 43},
  pages={26606-9}
}
We have isolated a murine cDNA encoding a ligand for the Cek5 receptor protein-tyrosine kinase (RPTK), a member of the Eph/Eck RPTK subfamily. Sequence analysis predicts an open reading frame of 345 amino acids with a predicted molecular mass of 38 kDa. Metabolic labeling and immunoprecipitation of cells transfected with a cDNA encoding the Cek5 ligand revealed the mature protein to have an apparent molecular mass of 45 kDa. The extracellular domain of the Cek5 ligand shows a 27% sequence… CONTINUE READING