cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase.

@article{Bourdi1995cDNACA,
  title={cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase.},
  author={Mohammed Bourdi and Damon R. Demady and Jennifer L Martin and Samer Jabbour and Brian M. Martin and John W. George and Lance R. Pohl},
  journal={Archives of biochemistry and biophysics},
  year={1995},
  volume={323 2},
  pages={
          397-403
        }
}
The function of a 58-kDa liver microsomal protein (P58) is controversial. To help clarify the physiological function of this protein, particularly in humans, a full-length human liver cDNA clone was isolated, sequenced, and expressed in milligram quantities with the use of a baculovirus expression system. The deduced amino acid sequence of the mature protein contained two thioredoxin-like active site motifs (CGHC) and in its C-terminus a nuclear localization motif (KPKKKKK), and an ER-retention… CONTINUE READING

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