cDNA cloning and assignment to chromosome 21 ofIFI-78K gene, the human equivalent of murineMx gene

@article{Horisberger1988cDNACA,
  title={cDNA cloning and assignment to chromosome 21 ofIFI-78K gene, the human equivalent of murineMx gene},
  author={Michel Andr{\'e} Horisberger and Marc G. Wathelet and Josiane Szpirer and Claude Szpirer and Quamrul Islam and G{\"o}ran Levan and Georges A. Huez and J. Content},
  journal={Somatic Cell and Molecular Genetics},
  year={1988},
  volume={14},
  pages={123-131}
}
Recently we have purified to homogeneity and characterized an interferon-induced human protein (p78 protein) which is the equivalent of the interferon-induced murine Mx protein responsible for a specific antiviral state against influenza virus infection. A cDNA library was constructed using mRNAs from interferon-induced human diploid fibroblasts. cDNA clones coding for the human p78 protein were identified and used to determine the chromosomal location of the corresponding gene (termedIFI-78K… 

Cloning and chromosomal location of human genes inducible by type I interferon

Two cDNA clones corresponding to human genes inducible by IFN-α are isolated by differential screening, termed IFI-4 and Ifi-54K, and it is shown that they are syntenic, unlike most of theIFN-inducible genes.

Four human Chromosome 3q and four human Chromosome 21 loci map onto sheep Chromosome 1q

The in situ localization of transferrin to sheep Chr 1q42-q45 confirms the previous assignment of this locus and independently anchors the eight new syntenic loci to Sheep Chromosome (Chr) 1q.

Chromosome maps of man and mouse. IV

Current knowledge of man‐mouse genetic homology is presented in the form of chromosomal displays, tables and a grid, which show locations of the 322 loci now assigned to chromosomes in both species,

Expression and stability of the Mx protein in different tissues of mice, in response to interferon inducers or to influenza virus infection.

The results indicate that the Mx protein is a sensitive, quantitative, and stable marker to follow IFN activity or virus infection in an animal model.

GART, SON, IFNAR, and CRF2-4 genes cluster on human Chromosome 21 and mouse Chromosome 16

One region of interest includes four genes, GART, SON, IFNAR, and the recently identified CRF2-4, from the chromosome band 21q22, which may contribute to developmental abnormalities of the central nervous system that result from elevated serum purine levels and abnormal adenosine metabolism.

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