cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.

@article{Marquardt2000cDNACG,
  title={cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.},
  author={Andreas Marquardt and Heidi Stoehr and Karen F. White and Bernhard H F Weber},
  journal={Genomics},
  year={2000},
  volume={66 2},
  pages={175-83}
}
The insertion of double bonds into specific positions of fatty acids is achieved by the action of distinct desaturase enzymes. Here we report the cloning and characterization of three members of the fatty acid desaturase (FADS) gene family in humans. Initially identified as cDNA fragments by direct cDNA selection within a defined 1.4-Mb region in 11q12-q13.1, full-length fatty acid desaturase-1 (FADS1) and fatty acid desaturase-2 (FADS2) transcripts were obtained by EST sequence assembly. A… CONTINUE READING
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