cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.

@article{Shindo1998cDNACE,
  title={cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.},
  author={Mitsuko Shindo and Hajime Nakano and Hidehito Kuroyanagi and Takuji Shirasawa and Motohiro Mihara and Debra J. Gilbert and Nancy A. Jenkins and Neal G. Copeland and Hideo Yagita and Katsuzumi Okumura},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={244 1},
  pages={
          285-92
        }
}
Chromosomal segregation during mitosis as well as meiosis is considered to be regulated by multiple kinases, but the precise mechanism remains largely unknown. A mutation in Drosophila, designated aurora, was identified as a responsible gene for a chromosomal segregation defect and encodes a putative serine-threonine kinase. Here we have identified mammalian aurora homologues, designated aurora-related kinase (ARK) 1 and ARK2. Kinase domains of murine ARK1 and ARK2 showed 61 and 62% identity… CONTINUE READING
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