cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase.

@article{Wright1993cDNACC,
  title={cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase.},
  author={Richard M. Wright and Gisela M. Vaitaitis and Curtis M. Wilson and Thomas Repine and Lance S. Terada and John E. Repine},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 22},
  pages={10690-4}
}
We isolated cDNAs encoding xanthine dehydrogenase (XD; xanthine:NAD+ oxidoreductase, EC 1.1.1.204) from a human liver cDNA library. The complete nucleotide sequence of human XD was determined; the deduced amino acid sequence encoded a protein of 1336 amino acid residues of M(r) 147,782. Human XD possessed many of the signature sequences typical of XDs from flies and rodents, including an unusual cysteine distribution, a potential 2Fe/2S binding site, and a putative molybdopterin cofactor… CONTINUE READING

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