cDNA Microarray Analysis of Changes in Gene Expression Induced by Neuronal Hypoxia in Vitro

@article{Jin2002cDNAMA,
  title={cDNA Microarray Analysis of Changes in Gene Expression Induced by Neuronal Hypoxia in Vitro},
  author={K. Jin and Xiao Ou Mao and Mark W. Eshoo and Gabriel del Rio and Rammohan V Rao and Dapeng Chen and Roger Simon and David Greenberg},
  journal={Neurochemical Research},
  year={2002},
  volume={27},
  pages={1105-1112}
}
We used cDNA microarray gene expression profiling to characterize the transcriptional response to exposure of cultured mouse cerebral cortical neurons to hypoxia for 24 hr. Of 11,200 genes examined, 1,405 (12.5%) were induced or repressed at least 1.5-fold, whereas 26 known genes were induced and 20 known genes were repressed at least 2.5-fold. The most strongly induced genes included genes coding for endoplasmic reticulum proteins (Ero1L/Giig11, Sac1p, Ddit3/Gadd153), proteins involved in… CONTINUE READING

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