cAMP stimulates protein kinase B in a Wortmannin-insensitive manner.

  title={cAMP stimulates protein kinase B in a Wortmannin-insensitive manner.},
  author={C L Sable and Nathalie Filippa and Brian A. Hemmings and E Van Obberghen},
  journal={FEBS letters},
  volume={409 2},
Activation of protein kinase B (PKB) by growth factors has been demonstrated to proceed via phosphatidylinositol 3-kinase (PI3-kinase). Here, we show that agents which raise intracellular cAMP can also stimulate PKB. However, this effect is not sensitive to wortmannin, indicating that it is PI3-kinase independent. This activation does not appear to result from direct phosphorylation by protein kinase A (PKA) since GST-PKB is not an effective PKA substrate. In addition, the activation pathway of… CONTINUE READING
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