cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J7774 macrophages.

@article{Bernard1991cAMPSC,
  title={cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J7774 macrophages.},
  author={David W. Bernard and Aar{\'o}n Rodr{\'i}guez and George H. Rothblat and Jane M. Glick},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 2},
  pages={710-6}
}
The regulation by cAMP of cholesteryl ester hydrolysis and net depletion of cellular cholesteryl ester (cholesteryl ester clearance) in J774 murine macrophages was explored. Using Sandoz 58035 to selectively inhibit acyl CoA:cholesterol acyltransferase, we showed that the absolute rate of cholesteryl ester hydrolysis was stimulated 2-fold in J774 cells by the cAMP analogues 8-(4-chlorophenylthio)adenosine 3':5'-cyclic monophosphate and dibutyryl-cAMP. The rate of hydrolysis was also stimulated… CONTINUE READING

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