cAMP-responsive element modulator α (CREMα) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE).

@article{Rauen2012cAMPresponsiveEM,
  title={cAMP-responsive element modulator α (CREMα) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE).},
  author={Thomas Rauen and Alexandros P. Grammatikos and Christian M Hedrich and Juergen Floege and Klaus Tenbrock and Kim Ohl and Vasileios C Kyttaris and George C Tsokos},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 51},
  pages={42525-32}
}
Notch signaling constitutes an evolutionarily conserved pathway that transduces signals between neighboring cells and determines major decisions in cell proliferation, survival, and differentiation. Notch signaling has been shown to play a pivotal role during T cell lineage determination. T lymphocytes from patients with systemic lupus erythematosus (SLE) display a severely altered phenotype with several molecular and functional aberrations, including defective capacities to up-regulate Notch-1… CONTINUE READING
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