cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.

@article{Hedrich2014cAMPRE,
  title={cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.},
  author={Christian M Hedrich and Jos{\'e} Carlos Crisp{\'i}n and Thomas Rauen and Christina Ioannidis and Tomohiro Koga and Noe Rodriguez Rodriguez and Sokratis A. Apostolidis and Vasileios C Kyttaris and George C Tsokos},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 4},
  pages={2361-70}
}
TCR-αβ(+)CD3(+)CD4(-)CD8(-) "double negative" T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative T cells have been claimed to derive from CD8(+) cells that down-regulate CD8 co-receptors and acquire a distinct effector phenotype that includes the expression of proinflammatory cytokines. This, along with the fact that double negative T cells have been documented in inflamed organs, suggests that they may… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…