cAMP response element-binding protein is required for stress but not cocaine-induced reinstatement.

@article{Kreibich2004cAMPRE,
  title={cAMP response element-binding protein is required for stress but not cocaine-induced reinstatement.},
  author={Arati Sadalge Kreibich and Julie A. Blendy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 30},
  pages={6686-92}
}
Reinstatement of previously extinguished conditioned place preference (CPP) is precipitated by stress or drug exposure. Here, we show that acute exposure to forced swim stress (FS), in a context distinct from conditioning, induces reinstatement of cocaine CPP in wild-type mice. This behavior is accompanied by a pattern of phosphorylated cAMP response element-binding protein (pCREB) activation in discrete brain regions that is distinct from the pattern observed after cocaine-induced… CONTINUE READING