cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts.

@article{Shimouchi1993cAMPRS,
  title={cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts.},
  author={Akito Shimouchi and Stephan P Janssens and Donald B Bloch and Warren M. Zapol and Kenneth D. Bloch},
  journal={The American journal of physiology},
  year={1993},
  volume={265 5 Pt 1},
  pages={L456-61}
}
Endothelium-derived relaxing factor (EDRF)/nitric oxide (NO) activates soluble guanylate cyclase, thereby stimulating the synthesis of guanosine 3',5'-cyclic monophosphate (cGMP). To investigate the regulation of this important EDRF/NO receptor, we studied soluble guanylate cyclase gene expression in a rat fetal lung fibroblast cell line (RFL-6). 3-Isobutyl-1-methylxanthine, forskolin, and dibutyryl adenosine 3',5'-cyclic monophosphate (cAMP), agents which increase intracellular cAMP, decreased… CONTINUE READING

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