cAMP protects endothelial barrier functions by preventing Rac-1 inhibition.

@article{Waschke2004cAMPPE,
  title={cAMP protects endothelial barrier functions by preventing Rac-1 inhibition.},
  author={Jens Waschke and Detlev Drenckhahn and Roger H. Adamson and Holger Barth and Fitz-Roy Curry},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 6},
  pages={H2427-33}
}
cAMP enhances endothelial barrier properties and is protective against various inflammatory mediators both in vivo and in vitro. However, the mechanisms whereby cAMP stabilizes the endothelial barrier are largely unknown. Recently we demonstrated that the Rho family GTPase Rac-1 is required for maintenance of endothelial barrier functions in vivo and in vitro. Therefore, in the present study we investigated the effect of forskolin (5 microM)- and rolipram (10 microM)-induced cAMP increase on… CONTINUE READING

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