cAMP neuropeptide agonists induce pituitary suppressor of cytokine signaling-3: novel negative feedback mechanism for corticotroph cytokine action.

@article{Bousquet2001cAMPNA,
  title={cAMP neuropeptide agonists induce pituitary suppressor of cytokine signaling-3: novel negative feedback mechanism for corticotroph cytokine action.},
  author={C Bousquet and Vera Chesnokova and Anastasia Kariagina and Audrey Ferrand and Shlomo Melmed},
  journal={Molecular endocrinology},
  year={2001},
  volume={15 11},
  pages={
          1880-90
        }
}
  • C Bousquet, Vera Chesnokova, +2 authors Shlomo Melmed
  • Published in Molecular endocrinology 2001
  • Biology, Medicine
  • The hypothalamo-pituitary-adrenal (HPA) axis maintains a homeostatic response to stress, infection, or neoplasia. Inflammatory cytokines, including leukemia inhibitory factor (LIF), stimulate the HPA axis either directly at the pituitary corticotroph, or indirectly through induction of CRH or sympathetic noradrenergic neurons, and mediate the immuno-neuroendocrine interface. Unrestrained HPA axis activation leads, however, to immunosuppression. Because suppressor of cytokine signaling-3 (SOCS-3… CONTINUE READING

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