cAMP-mediated regulation of cholesterol accumulation in cystic fibrosis and Niemann-Pick type C cells.

@article{Manson2008cAMPmediatedRO,
  title={cAMP-mediated regulation of cholesterol accumulation in cystic fibrosis and Niemann-Pick type C cells.},
  author={Mary E. Manson and Deborah A. Corey and Nicole M. A. White and Thomas Patrick Kelley},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={295 5},
  pages={
          L809-19
        }
}
The goal of this study was to identify a mechanism regulating cholesterol accumulation in cystic fibrosis (CF) cells. Both CFTR activation and expression are regulated by the cAMP pathway, and it is hypothesized that a feedback response involving this pathway may be involved in the phenotype of cholesterol accumulation. To examine the role of the cAMP pathway in cholesterol accumulation, we treated two CF model cell lines with the Rp diastereomer of adenosine 3',5'-cyclic monophosphorothioate… CONTINUE READING
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