cAMP-mediated growth inhibition of a B-lymphoid precursor cell line Reh is associated with an early transient delay in G2/M, followed by an accumulation of cells in G1.

@article{Blomhoff1988cAMPmediatedGI,
  title={cAMP-mediated growth inhibition of a B-lymphoid precursor cell line Reh is associated with an early transient delay in G2/M, followed by an accumulation of cells in G1.},
  author={Heidi Kiil Blomhoff and Rune Blomhoff and Trond Stokke and C deLange Davies and K Brevik and Erlend Smeland and Steinar Funderud and Tore Godal},
  journal={Journal of cellular physiology},
  year={1988},
  volume={137 3},
  pages={583-7}
}
This study was undertaken to gain more insight into the effects of cyclic adenosine monophosphate (cAMP) on cell-cycle progression in the B-lymphoid precursor cell line Reh. The adenylate cyclase activator forskolin reduced the proliferation of asynchronously growing Reh cells by 50% after 72 hr culture. Growth inhibition was associated with an accumulation of cells in G1. Furthermore, we demonstrated that forskolin provoked a delay of cells for approximately 10 hr in G2/M prior to the G1… CONTINUE READING

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