cAMP initiates early phase neuron-like morphology changes and late phase neural differentiation in mesenchymal stem cells

@article{Zhang2010cAMPIE,
  title={cAMP initiates early phase neuron-like morphology changes and late phase neural differentiation in mesenchymal stem cells},
  author={Linxia Zhang and Linsey C. Seitz and Amy M. Abramczyk and Li Liu and Christina Chan},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={863-876}
}
The intracellular second messenger cAMP is frequently used in induction media to induce mesenchymal stem cells (MSCs) into neural lineage cells. To date, an understanding of the role cAMP exerts on MSCs and whether cAMP can induce MSCs into functional neurons is still lacking. We found cAMP initiated neuron-like morphology changes early and neural differentiation much later. The early phase changes in morphology were due to cell shrinkage, which subsequently rendered some cells apoptotic. While… CONTINUE READING

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