cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities.

Abstract

To understand the underlying signaling events of polyunsaturated fatty acid-induced growth, we studied the effect of cAMP on early and delayed growth response events induced by linoleic acid in smooth muscle cells (SMC). cAMP significantly inhibited both basal and linoleic acid-induced DNA synthesis. Linoleic acid-induced early growth response events, such… (More)

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@article{Hu1998cAMPIL, title={cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities.}, author={Zhao Yong Hu and Nageswara R. Madamanchi and Geeta Rao}, journal={Biochimica et biophysica acta}, year={1998}, volume={1405 1-3}, pages={139-46} }