cAMP induces hypertrophy and alters DNA methylation in HL-1 cardiomyocytes.

@article{Fang2015cAMPIH,
  title={cAMP induces hypertrophy and alters DNA methylation in HL-1 cardiomyocytes.},
  author={Xiefan Fang and Jourdon Robinson and John Wang-Hu and Lingli Jiang and Daniel M. A. Freeman and Scott A. Rivkees and Christopher C. Wendler},
  journal={American journal of physiology. Cell physiology},
  year={2015},
  volume={309 6},
  pages={
          C425-36
        }
}
cAMP is a highly regulated secondary messenger involved in many biological processes. Chronic activation of the cAMP pathway by catecholamines results in cardiac hypertrophy and fibrosis; however, the mechanism by which elevated cAMP leads to cardiomyopathy is not fully understood. To address this issue, we increased intracellular cAMP levels in HL-1 cardiomyocytes, a cell line derived from adult mouse atrium, using either the stable cAMP analog N(6),2'-O-dibutyryladenosine 3',5'-cyclic… CONTINUE READING
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