cAMP-induced Interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation.

@article{Brenner2003cAMPinducedIP,
  title={cAMP-induced Interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation.},
  author={Susanne C. Brenner and Susanna Proesch and Katja Schenke-Layland and Ulrike Riese and Ulrike Gausmann and Cornelia Platzer},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 8},
  pages={5597-604}
}
The molecular mechanisms underlying the regulation of interleukin (IL)-10 transcription in monocytic cells by various stimuli during inflammation and the stress reaction are not fully understood. Recently, we provided evidence that stress-induced IL-10 promoter activation in monocytic cells is mediated by catecholamines via a cAMP-dependent signaling pathway including CREB/ATF (cAMP-responsive element binding protein/activating transcription factor) binding to two CRE motifs. However, the… CONTINUE READING