cAMP increases the basolateral Cl−-conductance in the isolated perfused medullary thick ascending limb of Henle's loop of the mouse

@article{Schlatter1985cAMPIT,
  title={cAMP increases the basolateral Cl−-conductance in the isolated perfused medullary thick ascending limb of Henle's loop of the mouse},
  author={Eberhard Schlatter and Rainer Greger},
  journal={Pfl{\"u}gers Archiv},
  year={1985},
  volume={405},
  pages={367-376}
}
The effect of cAMP on transepithelial and transmembrane potential differences and resistances was examined in isolated in vitro perfused mouse medullary thick ascending limbs of Henle's loop (mTAL). The effects of furosemide and barium were tested. Stimulation of NaCl transport by ADH 10−9+dbcAMP 4·10−4+forskolin 10−6 mol·l−1 (paired experiments) resulted in: a) an increase in transepithelial potential difference, referenced to the grounded bath, from +6.7±0.3 mV to +12.0±0.4 mV (n=47); b) a… CONTINUE READING