cAMP increases liver Na+-taurocholate cotransport by translocating transporter to plasma membranes.

  title={cAMP increases liver Na+-taurocholate cotransport by translocating transporter to plasma membranes.},
  author={Sunil Mukhopadhayay and Meena Ananthanarayanan and Bruno Stieger and Peter Meier and Frederick J. Suchy and Mohammed Sawkat Anwer},
  journal={The American journal of physiology},
  volume={273 4 Pt 1},
Adenosine 3',5'-cyclic monophosphate (cAMP), acting via protein kinase A, increases transport maximum of Na+-taurocholate cotransport within 15 min in hepatocytes (S. Grüne, L. R. Engelking, and M. S. Anwer. J. Biol. Chem. 268: 17734-17741, 1993); the mechanism of this short-term stimulation was investigated. Cycloheximide inhibited neither basal nor cAMP-induced increases in taurocholate uptake in rat hepatocytes, indicating that cAMP does not stimulate transporter synthesis. Studies in plasma… CONTINUE READING


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