cAMP enhances CSF-1-induced ERK activity and c-fos mRNA expression via a MEK-dependent and Ras-independent mechanism in macrophages.

@article{Wilson1998cAMPEC,
  title={cAMP enhances CSF-1-induced ERK activity and c-fos mRNA expression via a MEK-dependent and Ras-independent mechanism in macrophages.},
  author={Nicholas J. Wilson and Anthony Jaworowski and Alister C Ward and John A Hamilton},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={244 2},
  pages={475-80}
}
Inhibition of MAPK by elevated intracellular cAMP has often been correlated with suppression of growth factor-induced proliferation. However, in murine bone marrow-derived macrophages (BMM) we show that the cAMP analogue, 8-bromo cAMP (8BrcAMP) (1mM), despite being a dramatic G1 phase proliferation inhibitor, increased ERK activity both in the absence and… CONTINUE READING