cAMP detection methods in HTS: selecting the best from the rest

  title={cAMP detection methods in HTS: selecting the best from the rest},
  author={C. S. Williams},
  journal={Nature Reviews Drug Discovery},
The number of technologies that enable high-throughput functional screening of G-protein-coupled receptors has expanded markedly over the past 5 years. Consequently, choosing the most appropriate technology can be a daunting task, particularly for Gi- or Gs-coupled receptors. The most common systems for cyclic AMP detection are reviewed, highlighting the practical and theoretical aspects that are important in their application to high-throughput screening. Current technologies can do the job… CONTINUE READING

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Detection of β-lactamase reporter gene expression by flow cytometry

  • T Knapp
  • Cytometry 51A,
  • 2003

Development of an intact cell reporter gene β-lactamase assay for G protein-coupled receptors for high-throughput screening

  • P Kanupoli
  • Anal. Biochem. 314,
  • 2003

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