cAMP detection methods in HTS: selecting the best from the rest

@article{Williams2004cAMPDM,
  title={cAMP detection methods in HTS: selecting the best from the rest},
  author={C. S. Williams},
  journal={Nature Reviews Drug Discovery},
  year={2004},
  volume={3},
  pages={125-135}
}
The number of technologies that enable high-throughput functional screening of G-protein-coupled receptors has expanded markedly over the past 5 years. Consequently, choosing the most appropriate technology can be a daunting task, particularly for Gi- or Gs-coupled receptors. The most common systems for cyclic AMP detection are reviewed, highlighting the practical and theoretical aspects that are important in their application to high-throughput screening. Current technologies can do the job… CONTINUE READING

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