cAMP-dependent protein kinase phosphorylates and activates nuclear Ca2+-ATPase.

  title={cAMP-dependent protein kinase phosphorylates and activates nuclear Ca2+-ATPase.},
  author={Patrick J Rogue and Jean Paul Humbert and A Meyer and Solange Freyermuth and M M Krady and Anant Narain Malviya},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 16},
A Ca2+-pump ATPase, similar to that in the endoplasmic reticulum, has been located on the outer membrane of rat liver nuclei. The effect of cAMP-dependent protein kinase (PKA) on nuclear Ca2+-ATPase (NCA) was studied by using purified rat liver nuclei. Treatment of isolated nuclei with the catalytic unit of PKA resulted in the phosphorylation of a 105-kDa band that was recognized by antibodies specific for sarcoplasmic reticulum Ca2+-ATPase type 2b. Partial purification and immunoblotting… CONTINUE READING

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