cAMP-dependent protein kinase is essential for hypoxia-mediated epithelial-mesenchymal transition, migration, and invasion in lung cancer cells.

@article{Shaikh2012cAMPdependentPK,
  title={cAMP-dependent protein kinase is essential for hypoxia-mediated epithelial-mesenchymal transition, migration, and invasion in lung cancer cells.},
  author={Dooniya Shaikh and Qiyuan Zhou and Tianji Chen and Joyce Christina F. Ibe and J. Usha Raj and Guofei Zhou},
  journal={Cellular signalling},
  year={2012},
  volume={24 12},
  pages={2396-406}
}
Lung cancer is the leading cause of cancer-related death worldwide. Hypoxia is known to increase cancer cell migration and invasion. We have previously reported that hypoxia induces epithelial-mesenchymal transition (EMT) in lung cancer cells. However, it is unknown whether hypoxia promotes lung cancer cell migration and invasion via EMT and whether cyclic AMP (cAMP) dependent protein kinase (PKA) plays a role in this process. We found that hypoxia increased PKA activity and induced mRNA and… CONTINUE READING
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