cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain.

@article{Yang2011cAMPdependentPK,
  title={cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain.},
  author={Hong-Bin Yang and Xian Hui Yang and Jing Cao and Shuai Li and Yan-Ni Liu and Z W Suo and Hong-Bin Cui and Zhong Ning Guo and Xiaodong Hu},
  journal={Journal of neurochemistry},
  year={2011},
  volume={116 1},
  pages={93-104}
}
Selective inhibition of GluN2B-containing NMDA receptor (GluN2BR) in spinal dorsal horn effectively alleviates inflammatory pain, suggesting the up-regulation of GluN2BR function involved in central sensitization. Previous studies have demonstrated that the increase in GluN2BR synaptic expression serves as a key step to enhance GluN2BR function after intradermal injection of Complete Freund's Adjuvant (CFA). Here, we showed that cAMP-dependent protein kinase (PKA) played an important role in… CONTINUE READING
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