cAMP-dependent allostery and dynamics in Epac: an NMR view.

  title={cAMP-dependent allostery and dynamics in Epac: an NMR view.},
  author={Rajeevan Selvaratnam and Madoka Akimoto and Bryan M. B. VanSchouwen and Giuseppe Melacini},
  journal={Biochemical Society transactions},
  volume={40 1},
Epac (exchange protein directly activated by cAMP) is a critical cAMP receptor, which senses cAMP and couples the cAMP signal to the catalysis of guanine exchange in the Rap substrate. In the present paper, we review the NMR studies that we have undertaken on the CBD (cyclic-nucleotide-binding domain) of Epac1. Our NMR investigations have shown that cAMP… CONTINUE READING