cAMP activates transcription of the human glucocorticoid receptor gene promoter

@article{Peuelas1998cAMPAT,
  title={cAMP activates transcription of the human glucocorticoid receptor gene promoter},
  author={Iv{\'a}n Pe{\~n}uelas and Ignacio J Encio and Natalia L{\'o}pez-Moratalla and Esteban Santiago},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1998},
  volume={67},
  pages={89-94}
}
Glucocorticoids and cAMP regulate, either in a synergistic or additive fashion, the transcription of multiple genes, although some antagonistic effects of dexamethasone on cAMP-activated transcription have been described. The increased glucocorticoid receptor (GR) mediated response of some cell types, as a result of augmented cAMP, has been considered to be mainly due to an increased stability of GR mRNA, although other plausible explanations should not be ruled out. We studied the possibility… CONTINUE READING

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