cAMP Elevation Down-Regulates β3 Integrin and Focal Adhesion Kinase and Inhibits Leptin-Induced Migration of MDA-MB-231 Breast Cancer Cells

@inproceedings{Spina2012cAMPED,
  title={cAMP Elevation Down-Regulates β3 Integrin and Focal Adhesion Kinase and Inhibits Leptin-Induced Migration of MDA-MB-231 Breast Cancer Cells},
  author={Annamaria Spina and Francesca Di Maiolo and Antonietta Esposito and Luigi Sapio and Emilio Chiosi and Luca Sorvillo and Silvio Naviglio},
  booktitle={BioResearch open access},
  year={2012}
}
Breast cancer is one of the most common malignancies and a major cause of cancer death among women worldwide. The high mortality rate associated with breast cancer is mainly due to a propensity of the tumor to metastasize, even if small or undetectable. Given the relevant role of leptin in breast cancer growth and metastasis, novel strategies to counteract biological effects of this obesity-linked cytokine are warranted. Recently, we demonstrated that in MDA-MB-231 breast cancer cells… CONTINUE READING

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