c7E3 Fab inhibits human tumor angiogenesis in a SCID mouse human skin xenograft model

Abstract

The αvβ3 integrin plays an important role in tumor growth and angiogenesis. Inhibition of this receptor by intact bivalent antibodies has been shown to inhibit angiogenesis and tumor growth. In this study we tested the chimeric Fab of 7E3 (c7E3 Fab), an antibody reactive with human platelet GPIIb/IIIa and αvβ3 to determine if it would inhibit in vivo… (More)
DOI: 10.1007/s10456-006-9053-x

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