c-src is consistently conserved in the chromosomal deletion (20q) observed in myeloid disorders.

@article{Beau1985csrcIC,
  title={c-src is consistently conserved in the chromosomal deletion (20q) observed in myeloid disorders.},
  author={Michelle M Le Beau and Carol A. Westbrook and Manuel O. Diaz and Janet D. Rowley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 19},
  pages={6692-6}
}
The proto-oncogene c-src has been mapped to two bands in human chromosomes, 1p36 and 20q13, both of which are involved in rearrangements in human tumors. In particular, deletions (loss of part of a chromosome) of the long arm of chromosome 20, del(20q), are commonly observed in hematologic malignant diseases. By using in situ chromosomal hybridization of a c-src probe to metaphase cells prepared from leukemic bone marrow cells of three patients with a del(20q), we observed specific labeling on… CONTINUE READING

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