c-myc is a downstream target of the Smad pathway.

  title={c-myc is a downstream target of the Smad pathway.},
  author={Ken Yagi and Masao Furuhashi and Hiromasa Aoki and Daisuke Goto and Hiroyuki Kuwano and Kazuo Sugamura and Kohei Miyazono and Mitsuyasu Kato},
  journal={The Journal of biological chemistry},
  volume={277 1},
c-Myc is one of the most potent regulators of cell cycle progression in higher eukaryotes. Down-regulation of c-Myc is a critical event for growth inhibition induced by transforming growth factor-beta (TGF-beta) and is frequently impaired in cancer cells. We determined a Smad-responsive element in the c-myc promoter. This element is a complex of the TGF-beta1 inhibitory element (TIE) originally identified in the transin/stromelysin promoter and an E2F site responsible for transcriptional… CONTINUE READING