c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation.

@article{Miner1991cmycIO,
  title={c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation.},
  author={Jeffrey H Miner and Barbara J. Wold},
  journal={Molecular and cellular biology},
  year={1991},
  volume={11 5},
  pages={2842-51}
}
In vertebrate development, a prominent feature of several cell lineages is the coupling of cell cycle regulation with terminal differentiation. We have investigated the basis of this relationship in the skeletal muscle lineage by studying the effects of the proliferation-associated regulator, c-myc, on the differentiation of MyoD-initiated myoblasts. Transient cotransfection assays in NIH 3T3 cells using MyoD and c-myc expression vectors demonstrated c-myc suppression of MyoD-initiated… CONTINUE READING

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